Core Technology 1: Technique for Inducing Mesenchymal Stem Cells (MSCs) from iPS Cells via Neural Crest Cells

This technology, established at the Ikeya Laboratory of Center for iPS Cell Research and Application (CiRA) allows for the inexpensive and stable production of high-quality MSCs in large quantities, suitable for mass production of products.

Related Paper:Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage (

Core Technology 2: Technique for 3D Tissue Structuring with Bio-3D Printer

This technology, established in the Nakayama Laboratory of Department of Regenerative Medicine and Biomedical Engineering, Faculty of Medicine,Saga University, involves inducing cartilage cells from MSCs obtained through Core Technology 1, followed by a maturation process to create 3D-modeled cartilage implants.

Related Paper:Bio-3D printing iPSC-derived human chondrocytes for articular cartilage regeneration